Monday, July 1, 2013

Reactive Oxygen Species (ROS): an inevitable consequence

Lipid peroxidation markers are elevated in autism, according to a report from the Autism Research Institute, indicating oxidative stress is increased. Cellular consequences of decreased glutathione antioxidant potential may be possible implications for symptoms of autism. The potential role of oxidative stress in the etiology of autism has received less research attention. So what in the world is oxidative stress? An explanation from Wikipedia defines it as: an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals which can damage all components of the cell, including proteins, lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. Visit Wikipedia for the full article.
Diagram Source: NIST,National Institute of Standards and Technology
In a statement from Nathanial le Roy Darnell, Research Analyst, Diabetes Support Services, Inc. in Oregon, “Diabetics also suffer from chronic oxidative stress. We use diatomic hydrogen with our clinical population. It improves insulin sensitivity, stabilizes serum glucose levels, reduces LDL cholesterol, lowers hBA1c, and significantly suppresses systemic inflammation. Biomarkers begin changing measurably within six days. A recent double-blind placebo-controlled trial with Parkinson’s patients using hydrogen therapy demonstrated significant improvements in total Unified Parkinson's Disease Rating Scale (UPDRS) scores among all patients involved. Diatomic hydrogen is the only antioxidant capable of immediately arresting intracellular and intracerebral oxidation.”